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First, storing and accessing multiple information sources can be challenging for organisms of modest to large genome size, for which we implemented a web server to handle storage and facilitate access (See Supplemental Methods in the Additional File 1).

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These constraints lead to a different algorithm for detection which we implemented in the system: detection of long horizontal and vertical lines followed by the extraction of the TV screen rectangle.

We provide source code for all the presented methods, which we implemented as modules for GRASS GIS, so that they can be used together with other open source geospatial processing tools [40].

In this study, we report on our updated CCC version 2 (v2) classification system, which we implemented for both the ICD-9 and ICD-10 coding schemes.

An alternative method for estimating transmission rates, which we implement when estimating the strength of TD (see Discussion), is to calculate the maximum-likelihood estimate, θ p1, of the probability of transmitting the overrepresented allele from the parental sex of interest, when the opposite parent's transmission rate is set to θ p2 = 0.5.

This inspired us to develop a new approach, approximate hierarchical clustering, for which we have implemented a fast algorithm HappieClust.

Steps (4) to (7) comprise the actual gene mention normalization task, for which we have implemented a range of filters to remove likely false positive gene mentions as well as candidate IDs.

Both lakes have geographically distinct char spawning sites (PAL; P1 - 3, TUN; T1 - 2) for which we assess population connectivity implementing 10 microsatellites.

It is systematic and can be implemented for any condition for which we have a good quality reference study to model the risk of the condition.

2,3,4 Thank you for this suggestion, which we have implemented in the revised version of our manuscript.

We propose to use this algorithm, which we have implemented for the Poisson and negative binomial distributions.

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