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Hot Snap, though, looks like the sort of horse for which trials were designed, desperately in need of experience but beautifully bred, full of potential and now much more likely to show her best form when it matters most.
Agents currently under trial or for which trials are planned based on promising results in animal models include anti-B-cell therapy (anti-CD20 and anti-CD22); CTLA-4Ig (cyctotoxic T-lymphocyte associated antigen 4/immunoglobulin), which impairs T cell co-stimulation; anti-cytokine approaches directed against BlyS, interleukin-10, tumor necrosis factor-α, and IFN-α; and TLR inhibition [ 51].
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Legend: PRO compliance rate was clearly reported for 6 of the 26 RCTs for which trial protocols were obtained.
Most therapists reported the routine use of flexion-based exercise, reflecting recommendations in the literature which are based on theoretical benefits, but for which trial evidence is lacking.
In 2004, the group published guidelines that rated Xigris more highly than older treatments for which clinical trials treating sepsis had never been conducted.
At the present time, the primary types of functional hemodynamic monitoring for which clinical trials have shown clinical usefulness are related to predicting volume responsiveness and identifying occult cardiovascular insufficiency (compensated shock).
Investments of more than $600 million over the past decade have resulted in a robust global TB vaccine portfolio comprised of more than 25 early stage discovery leads and preclinical candidates, and a dozen candidates for which clinical trials are underway.
Electronic medical records can help answer clinical questions for which clinical trials are challenging to conduct.
This pragmatic study provides the most robust evidence to date on this important hypothesis for which classic trials are unlikely.
In addition, there are 131 drug combination usages, for which clinical trials reported ambiguous conclusions or produced statistically insignificant results.
This was particularly true for laser coagulation, for which many trials failed to report power settings, temperature, and site or duration of laser application.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com