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Transcription factor libraries provide genome-wide approaches that can be applied towards the development of TFZFs specific for virtually any gene or desired phenotype and may lead to the discovery of new genetic functions and pathways.
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Genome-wide RNAi libraries that allow for efficient knockdown of virtually any gene are now available for studying organisms ranging from C. elegans to human [ 2- 7].
The siRNAs, on the other hand, represent a fast, cost-effective, and relatively simple tool for inducing downregulation of virtually any gene sequence in many species.
The function of virtually any gene can now be assayed in virtually any cell type, presumably including non-dividing primary cells if a lentivirus packaging system is employed.
But the warrant permitted a fishing expedition for virtually any gun and any evidence of gang-related activity.
The availability of assembled whole-genome sequence information would facilitate the efficient design of assays for virtually any gene/s using this method.
Scientists have learned that they can turn off virtually any gene they want by inserting into cells short snippets of double-stranded RNA corresponding to the gene of interest.
In this respect, zinc finger protein DNA-binding domains can be engineered to target virtually any gene.
The power and utility of RNAi to suppress virtually any gene of known sequence has lead to its rapid adoption as an essential tool for understanding gene function and the elucidation of biological processes.
Thus, in principle, it should now be possible to obtain an accurate gene expression profile for virtually any C. elegans cell throughout development.
Due to the presence of "silent mutations" in optimized genes, sequence-optimized constructs can be employed for virtually any RNAi rescue experiment.
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