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The RSDs were acceptable in most cases, even for very low doses.
However, higher survival was observed for very low doses at the periphery of the irradiation field, whatever the dose delivered at the isocenter.
Previous studies have shown that the bioavailability of EtOH is < 1 for very low doses of EtOH suggesting a possible "first‐pass" effect (Gentry, 2000; Wilkinson et al., 1977).
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In addition, a Tier 0 assessment can help minimize the effort of performing a Tier 1 assessment by screening out exposures that produce low concern based on a finding of very low doses for all chemicals reaching a receptor.
The use of very low doses of lenalidomide and vigilance for tumor lysis syndrome is warranted.
Beekeepers in Italy and France also blame another neonicotinoid, thiamethoxam, produced by Syngenta, for killing their bees and studies have shown how bees' flight could be adversely affected by the absorption of very low doses.
Repeated administrations of drug-loaded erythrocytes at 4-week intervals for 15 months showed that very low doses of glucocorticoids provide significant improvement in FEV1 values and significant reduction of infective relapses due to Pseudomonas aeruginosa without adverse effects.
We analysed separately aspirin and other NSAIDs since in our population aspirin is often taken irregularly or at very low doses for secondary prevention of cardiovascular diseases, a fact that may mask some effects.
42 Clozapine is used in schizophrenia refractory to other medications and in bipolar disorders; it has been shown to be very effective at very low doses for the management of psychosis in elderly patients with Parkinson's disease, schizophrenia, and dementia (off-label use in dementia).
In this article we demonstrate for the first time that very low doses of BPA (picomolar or nanomolar) stimulate human seminoma cell proliferation by allowing a rapid, nongenomic, membrane-initiated activation of PKA and PKG signaling pathways associated with phosphorylation of the transcription factor CREB and the cell cycle regulator Rb.
For NSAIDs and coxibs, no extreme variation in dose was envisaged, but the analysis plan allowed for exclusion of very high or very low doses if these were outside the usual daily dose range (for example, ibuprofen 800 to 2,400 mg/day, diclofenac 50 to 150 mg/day and naproxen 500 to 1,000 mg/day).
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