After a qualitative analysis of all traces for all subjects and as illustrated for these three typical trials of the same subject, several important differences were observed.
Target gratings were presented at fixation (see Fig. 5 for a typical trial).
On average each odor was presented ten times and odor presentations were spaced 20 s apart (see Fig. 2 for a typical trial time protocol in the odor presentation).
The RRRs in PUB rates range from 47%to50%0% for coxibs versus nsNSAIDs in typical trials [ 16, 22, 96, 97].
The UC-PRO/SS was developed based on data collection from concept elicitation and cognitive interviews of subjects with moderate to severe UC who were representative of the UC target population eligible for typical clinical trials.
Typical trials are described and results are given for trials on an easy-to-grind AISI 52100 material using conventional speed and different abrasives including alumina, sintered ceramic SG alumina and CBN.
An example is given for a hypothetical typical trial of 250 patients, which for 80% power and 5% two-sided significance would correspond to a Cohen's effect size of 0.355 (about halfway between the 'small' and 'moderate' thresholds).
