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We also adjusted for treatment completion (as scheduled vs. with dose reduction vs. ended before scheduled) (table 2).
It showed a possible (albeit plausibly due to chance) benefit from offering a financial reward to DOT supervisors (85.7% versus 77.6% for treatment completion, p = 0.15).
Of these last patients, a 65-year-old women suffered from grade 3 diarrhoea, which eventually recovered allowing for treatment completion.
In striving to improve outcomes globally for curable childhood cancer conditions such as retinoblastoma, opportunity arises to include Stages of Change models for treatment completion, within the reality of lived cultural and cost contexts.
The treatment was provided on monthly basis at the doorstep after the case confirmation by a medical doctor and patients were monitored for treatment completion and for any side effects.
While Stages of Change models have been effectively utilized in cancer screening programs within settings of economic and cultural barriers, this application of health behavior theory has been limited to cancer screening rather than a comprehensive framework for treatment completion.
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In contrast to the low acceptance and completion of latent TB infection treatment, high rates of treatment completion for active TB cases can be achieved with directly observed therapy supported by public health regulations (11, 12).
In clinical practice, it might thus be relevant to raise patients' expectations to increase the chance of treatment completion, for example, by promoting patients' self-efficacy or providing a strong treatment rationale (Constantino et al. 2012).
Although new drugs are being developed, efforts must target prevention of XDR TB and its transmission, earlier identification of cases, support of treatment completion for TB and MDR TB, and greater use of antiretroviral therapy for patients who are co-infected with HIV.
The study identified predictors of treatment completion and outcome for adults and adolescents, and predictors of outcome by setting for adults.
Of the latter the outcome of previous treatment had been cure for 20, treatment completion with no smear results for 16, failure for 7 and default for 17.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com