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A high preference for AT → GC transitions was observed in condition D, whereas a high preference for transitions over transversions was observed in condition C. All of the mutations observed in condition E were transversions.
Qβ replicase showed an equal preference for inserting A/T or G/C changes, with minimal bias for transitions over transversions.
Mut II showed a somewhat reduced preference for transitions over transversions but still strongly favored A/T changes over G/C changes.
We show that Qβ replicase generates all possible base substitutions with an equivalent preference for mutating A/T or G/C bases and with no significant bias for transitions over transversions.
In addition, a clear bias for transitions over transversions was observed in the leader-coding domain in comparison to the Tv/Ts ratio within the intron and the mature toxin-coding domain (Fig. 6C).
Our analysis showed that EP-PCR exhibited a typical and well documented bias for A/T over G/C changes and a strong preference for transitions over transversions [ 7, 8].
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"Within the last year, we talked about a plan for transition over a number of years, and I think we agree on a plan and seeing the transition for Sabina over the next several years.
The degeneracy of the genetic code and the selective pressure for gene conservation have been suggested as the main reasons for the preponderance of transitions over transversions [ 13].
A distinct bias for nucleotide transitions over transversions was evident, with 87% substitutions being transitions.
In lasR, missense substitutions prevailed (86%), with a 2∶1 ratio for transitions (57%) over transversions (29%) (Figure 1B), which mainly produced changes in the amino acid sequences (Table 2).
For example, in Type I neurons the fluctuations near the slow manifold allow for reliable spiking transitions over a smaller range of action levels, with greater variation in the precision.
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