There is a need for thorough knowledge of solid-state transformations in order to implement quality by design (QbD) methodology in drug development.
For me this was by far the most important element - there's no substitute for thorough knowledge of your material.
Ironically, the very experience requisite for thorough knowledge of an object places the knowledge under a veil of doubt since experience inevitably carries the imprint of the noetic agent's subjective history, emotions, and desires.
As an educator e.g., in Skolen for livet (1838; "Schools for Life")—he stressed the need for the thorough knowledge of the Danish language and of Danish and biblical history, in opposition to those who favoured the study of the classics in Latin.
An increasing focus on hospital productivity has rendered a need for more thorough knowledge of cost drivers in hospitals, including a need for quantification of the impact of age, case-mix and other characteristics of patients, as well as establishment of the cost-quality relationship.
However, this tactic also has a disadvantage, for a thorough knowledge of the life cycle and thorough mastery of ways to handle a given organism in the laboratory are obviously of great importance to the researcher, and one can never know several organisms as well as one can know a single one.
There, one could acquire a reputation for having a thorough knowledge of the law and for being able to speak well in public.
The authors wish to thank Mr. Francisco Ponce from the Chilean Under-Secretariat for Fisheries, for the sharing of his thorough knowledge and understanding of the historic evolution of this fishery and the fisheries regulations in Chile.
Although several applications of MF-FRP strengthening on reinforced concrete (RC) structures are already available, further experimental and theoretical studies are needed for both achieving a thorough knowledge of their mechanical behaviour and formulating sound design rules.
As he remarked, the Sefer ha-emuna ha-rama was not for readers who, in their simplicity, are satisfied with what they know of religious tradition or for those who have a thorough knowledge of philosophy.
Subsequently, the article provides a thorough knowledge basis for each monomer used in non-polar dispersion polymerization, with a focus on the evolution of the technique, including progress in controlling the final particle characteristics and in designing novel effective stabilizers.
