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The architecture of this domain is homologous to chain A of the well-characterized histone acetyltransferases Gcn5, Gna1, Hpa2 in S. cerevisiae, suggesting a possible role for this transcript in regulating transcription via histone acetylation (Marchler-Bauer et al., 2011).
Consistent with a causal role for this transcript, further sequencing of our cohort of late-onset-FCD-affected individuals identified two cases harboring the same nonsense mutation and a further three unrelated individuals bearing a second missense allele.
The ToxoGeneChip does not include a probe for this transcript as there is no gene prediction at this locus.
For this transcript, microarray results indicated a pregnancy-related regulation, while real time RT-PCR revealed no changes in expression across the experimental conditions.
However, the buildup of β-F1-ATPase during cellular proliferation occurs in the absence of changes in the cellular abundance of its mRNA consistent with the stringent translational control described for this transcript [21] [25].
Although the sensitivity of the qRT-PCR for this transcript was below that for ORF73, the number of molecules covering the intergenic region was higher than the number of ORF73 transcripts.
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With thanks to Alan Fine and EMI for providing this transcript.
We did not consider the orientations of the retrogenes and the Ensembl transcripts for this analysis (transcripts on the sense or anti-sense strands of the retrogenes were treated equally).
Lauren Cochrane, reporting the show for the Guardian, filed this transcript of exactly what McCartney said.
Therefore we focused on this transcript for investigation.
For this viral transcript the linear dynamic range spanned from ten copies to one million copies (highest tested).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com