Thus, for the specific receptors showing this evolutionary pattern (Additional file 1: Table S3), such sequence conservation may indicate functional importance, e.g. recognition of essential odorants essential for the species as a whole.
However, recent findings have shown that looking for such a high affinity binder for a specific receptor is not crowned with success in every case.
Considering these results, methods for measuring specific receptor densities in human tumours, either from biopsies or using imaging techniques, appear useful for predicting vascular response to vasoactive agents.
BP in HGGs with uptake was 1.03 ± 1.11, and it correlated with tumor SUVmax (r = 0.868, P < 0.001; Figure 1B) and tumor-to-skin SUVmax ratio (r = 0.956, P < 0.001), implicating that SUVmax in this setting is a good marker for specific receptor binding.
The authors present a very intriguing behavioral analysis of the navigation of Drosophila larvae using optogenetically induced fictive olfactory and gustatory stimuli for specific receptor neurons and for receptor neurons in combination.
Dispersion models, run for hourly time intervals and controlled by measurements, are therefore used to provide estimates for specific receptor points.
Molecular modeling studies exposed a large cavity in the vicinity of the 4-position of 4-PIOL, in which there seems to be additional sites for specific receptor interactions.
Binding experiments of ANP to isolated leaf membranes provide evidence for specific receptor ligand interactions [ 8].
With respect to pathophysiological relevance of these receptors and the circuits that ligand-receptor pairs might produce, a great help to elucidate functions derives from the use of mice nullified for specific receptor subtypes.
This is a specific receptor for hyaluronic acid (HA), and HA is known to stimulate spreading, migration, invasion, and metastasis of cancer cells [11 14, 17].
