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Ecosystem models provide a platform for this progression, potentially offering a holistic view of ecosystems where, guided by the mechanistic understanding of processes and their connection to the environment and biota, large-scale questions can be investigated.
But what have we to show today for this "progression"?
Further deterioration in insulin sensitivity or secretion may enhance the risk for this progression.
One reason for this progression is that the effect of other factors on outcomes is likely to increase along the pathway.
More sophisticated experimental paradigms are necessary to distinguish whether it is the AAV vector itself, transcribed messenger RNA or Flag-TDP protein that is the molecule responsible for this progression, which is a prime objective for our future study.
Unpublished results (Brown AK, Conaghan PG, Karim Z ,Quinn MA, Ikeda K, Peterfy CG, Hensor E, Wakefield RJ, O'Connor PJ and Emery P) suggest that subclinical inflammation detected by imaging accounts for this progression and may provide a rationale for treating these patients in apparent remission with an anti-TNF agent.
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The search for markers of this progression have revealed IGFBP-2 and PTEN to be strongly associated; our findings provide a mechanistic link between these two putative markers which identifies potential new targets for improving therapeutic response.
The phase structures in 'Additional file 4: Phases for Figure 9' confirm this progression; SW3 indicates the presence of lower-order modes than SW1, and the symmetry vs. antisymmetry of the phases for SW4 follow those of the amplitude structures in Figure 9 and are furthermore simpler than the phase structures for SW3.
However, demyelinating lesions continue to expand after transplantation usually for 12 18 months, before this progression is arrested.
This progression for search engines toward becoming answer engines is crucial, particularly given our increased reliance on mobile devices.
Its transformation had happened so seamlessly that only by looking through my notes and photos from the previous six months did I see this progression for what it was: radicalisation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com