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Within CAESAR we developed tens of predictive models for this endpoint.
Our models, like other models for this endpoint, are based on available data.
They observed that log P O/W was not related to body burden, while water solubility or soil partition coefficients were better estimators for this endpoint.
In the SOHN built in the previous section, the general hypotheses (first level above the root) with a positive signal (mutagenic activity) correspond to common structural alerts for this endpoint.
Cox proportional hazards models were used to estimate crude and adjusted hazard ratios for this endpoint.
The meta-analysis focused on total malaria episodes, the important public health outcome, rather than first episodes so it may have overestimated PE for this endpoint.
There were no historical control data provided for this endpoint.
This has substantial implications for establishing exposure limits for this endpoint.
For this endpoint, the probability of remission by 26 weeks was approximately 67% (Table 4).
Death and second transplants for primary graft failure were considered competing risks for this endpoint.
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Furthermore, the availability of numerous controlled human studies makes reliance on animal data unnecessary for evaluating this endpoint.
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