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The reason for this downfall may be multifold from incomplete understanding of the patho-physiology of disease, incomplete understanding of mechanism of action of the therapy, in-appropriate application in clinical practice, in-efficient therapy development related to flawed trial design, regulatory impediments placed on the trials or deficits in application of scientific techniques.
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While this scene makes for the downfall of this movie, the real fault is in its plot.
These moves could create conditions for the downfall of this bloody despot and not leave us twiddling our thumbs in the hopes that rumors of Saddam's deteriorating health prove true.
Some slogans simply call for the downfall of Isis.
Demonstrators started calling for the downfall of the government.
From a small stage, a steady queue of speakers call for the downfall of the regime.
Syrians were not, at least initially, calling for the downfall of President Bashar al-Assad.
Were it not for the downfall of Yugoslavia, there would be no official number at all.
Mr. Rogers contended that the review exaggerated United States responsibility for the downfall of the Chilean president Salvador Allende.
He condemned those who used slogans for the downfall of the Islamic Republic and the supreme leader.
Many of those against the proposed charter chanted for the downfall of Mr. Morsi, Egypt's first democratically elected president.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com