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This review summarizes preclinical and clinical data for aflibercept and discusses future directions and clinical trials for this agent.
Low prevalence dominant driver lesions such as the FGFR-TACC fusion may represent a niche role for this agent class.
Since polymerase chain reaction (PCR) is a highly sensitive and specific method for the detection of infectious agents in animals, it was considered useful to develop a PCR method specific for this agent.
These trials will be important in establishing a role for this agent in the adjuvant setting and will hopefully lead to the development of more effective adjuvant chemotherapy regimens in the future.
The real-time imbalance of the wind farm was used as an input for this agent.
A key issue for this agent is how to map the SLA metrics to the observable metrics.
Clinical trials in humans must examine carefully the therapeutic-toxic ratio in dose-escalation protocols to determine the optimal dosage strategy for this agent.
However, it should be noted that the minimum inhibitory concentrations for atorvastatin, in particular, in the work by Masadeh, exceed by at least 100-fold the maximum serum concentration for this agent seen in human subjects with standard dosing [33].
"So for this agent, it may be desirable to get rid of humans.
Importantly, pharmacogenetic factors explain a significant portion of inter-patient variability and improves the accuracy of a developing population PK model for this agent.
Similar to the other macromolecules, the blood flow rate in most vessels is faster than extravasation for this agent, allowing the probe to fill the full length of the vessel.
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