Drugs mentioned above not only develop new leads for therapeutic development in AD, but also discover new chemical probes for use in understanding HSP70 biology.
Sigma receptors display diverse biological activities and represent potential fruitful targets for therapeutic development in combating many human diseases.
Thus, PPMO appear promising as candidates for therapeutic development against alphaviruses.
The aim of this review is to highlight recent efforts toward synthetic design for therapeutic development.
Parasitic diseases cause ∼500,000 deaths annually and remain a major challenge for therapeutic development.
Currently there are no KLK4-specific small-molecule inhibitors available for therapeutic development.
Therefore, 10c could be used as a new lead compound for therapeutic development.
Compounds LCL85, LCL120, LCL385, LCL284, and LCL204 were identified to be promising lead compounds for therapeutic development.
Transcription factors with aberrant activity in disease are promising yet untested targets for therapeutic development, particularly in oncology.
Dysregulation of these enzymes can lead to serious diseases in humans, and they are targets for therapeutic development against diabetes.
Development of inhibitors to modulate MMP activity has been an active area of investigation for therapeutic development.
