Suggestions(2)
Exact(4)
A property unique to the class III isoforms is that they normally signal as membrane-bound ligands suggesting that this may be important for their transforming activity.
Several oncogenes require an intact IGF-1R pathway for their transforming activity and moreover, disruption or inhibition of IGF-1R activity has been shown to inhibit the growth and motility of a wide range of cancer cells in vitro and in mouse models.
Transcription factors HoxA9 and HoxB4 are better known for their transforming potential via enhancing HSC self-renewal and abnormal myelopoiesis upon upregulation (Cao et al., 2005; Strathdee et al., 2007).
To date there is no evidence for their transforming ability in vivo using transgenic mice.
Similar(56)
Importantly, the collaboration between HoxA9 and TALE proteins is suggested to be essential for their respective transforming capacities.
Two such intermediates, FPP and GGPP modify many oncogenic proteins, including Ras and Rho GTPase for their malignant transforming activity (Jackson et al, 1990; Colditz et al, 2006).
The architectural pictures, for their part, transform solid, assertive structures into studies in evanescence, making the ordinary world look serenely strange.
The company has been flogging their transforming bike for about a year now but it looks like they're finally shipping in the US for $1,495.
Also, states applying for the flexibility must sketch their plans for transforming their lowest-performing schools and for establishing new ways to measure the performance of teachers and principals.
The bank's new bosses may yet prove to be no better than its old (who were once feted for their innovation in transforming a sleepy old building society into a securitisation dynamo).
As we explore in this article, this transformation was deliberately wrought by political elites in order to mobilize civilian raiders for their own ambitions, transforming what was once a feature of life in pastoralist communities into a tool for struggle over political power.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com