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Lineage specification in the haematopoietic system is highly regulated at the transcriptional level, and for many lineages specific transcription factors have been identified as critical for their specification.
In safety applications, as mentioned previously, requirements are expressed differently using RAMS attributes and a process for their specification and demonstration is exposed in CENELEC standards [3, 4].
Fate mapping, however, reveals that intermediate cells rather than K5-BCs are progenitors in the adult regenerating urothelium, that P cells, a transient population, are progenitors in the embryo, and that retinoids are critical in P cells and intermediate cells, respectively, for their specification during development and regeneration.
If the additional R7 cells in D-cbl clones result from hyper-activity of Sev, then these cells should require sev for their specification.
Taken together, these results indicate that TERT function is likely to be required for progenitor blood cell differentiation, and could also be required for their specification, maturation, and survival.
Thus, Pax8 seems to be required for the survival of thyroid cell precursors but not for their specification.
Similar(49)
The Committee set higher standards for dissolution of oral generic drug formulations than those in place for their specifications by comparing the dissolution profiles of the generic with those of originator products.
Determining the detailed molecular organization of specific somatosensory neuron subtypes is however necessary for our understanding of their specification, normal function and contribution to disease.
On the basis of their specifications for an effective search in a search engine, we developed a two-term search strategy combining one of three different CPG terms and one of nine MeSH terms for a specific disease.
This estimate is larger than that found by Sjoquist and Winters (forthcoming) for their baseline specification, possibly because HOPE is an especially large merit program.
acj6 expression is found in neurons at multiple points along sensory pathways, and is required for their proper specification and wiring [20], [21], [27].
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