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Influence of the mean stress was observed until a given stress ratio for the total analysed ΔK range, including the near threshold crack growth.
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For the total sample analyses, in the absence of a clear prior, the sequences without any time information were assigned an average time within the range of times available for other sequences (22 130 KYA, we used an unweighted average: 76.0 KYA, which is close to the weighted one: 59.6 KYA).
For the total volume analyses, we divided total volume by size of the population over 15 years old to control for population growth (using yearly population estimates from the World Bank 20).
For the total DW analyses, the results were tested for a normal distribution and subsequently tested for statistical differences using the t-test with a two-tailed distribution and unequal variance.
We note, however, that if the P-values of our top associations were corrected for the total number of analyses in a Bonferroni manner, they would not remain genome-wide significant.
Therefore, all of the following analyses were computed for the total sample, and separate analyses were performed for participants with and without chronic conditions.
A Galbraith plot was selected to explore the source of heterogeneity for total analyses.
Results of the Cox regression analyses for the total study sample as well as the analyses stratified according to age are presented in Table 2.
The heterogeneity test showed a lack of significant heterogeneity for the total, subgroup, and sensitivity analyses.
For the total risk ratios, the analyses were performed controlling for patient sex, calendar year, age group and diagnostic group.
Both for the total and the subgroup analyses the appropriate tests do not reveal any major heterogeneity between the trial results.
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