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Moreover, discrete-time guidance and control algorithms for the terminal phase, which is based on proportional navigation, are performed.
Costs for the terminal phase of care were assumed to be priced in the same way as the continuing phase.
In contrast, there was a considerably greater cytotoxic effect when the drug was examined at low concentrations for periods similar to those described for the terminal phase of adriamycin clearance.
The t1/2 of NC-6004 at 120 mg m−2 was longer than that of cisplatin at an equivalent dose, 14.6 min for the initial phase and 73.8 h for the terminal phase (Kitajima et al, 1987).
Because of the nonlinear nature of the PK data and insufficient data for the terminal phase of the concentration-time profile, the half-life of AMG 108 could not be determined.
The elimination half-lives of clevidipine observed after 72 h are similar to those obtained after a 20-min infusion in healthy volunteers at a final dose rate of 3.2 μg/min/kg (approximately 16 mg/h), reported as 0.6 and 2.3 min for the initial two rapid elimination phases (accounting for about 95%% of the area under the concentration time curve) and 16 min for the terminal phase [ 8– 10].
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The median (range) r2 for the linear regression of the terminal phase of the curve was 0.98 (0.87–0.99) and the fraction of AUC extrapolated beyond the last sampling time point was less than 6%.
When compared with the mean total clearance (18.6 24.8 L/h/m) and mean volume of the terminal phase (527 935 L/m) for paclitaxel in Japanese patients following the administration of nab-paclitaxel alone (80 300 mg/m), there were no obvious differences between those results and the results of this study.
For each individual the terminal elimination rate constant (λz) was determined by log-linear regression of the terminal phase of the plasma concentration time curve.
Costs associated with entering the state Death were based on costs for patients in the terminal phase of ESRD reported by van Hout et al [ 21]. (Table 2).
After imposing the disease/health problem categorisation, the model hypothesises that the disease burden can potentially be addressed by intervening through: i) primary prevention targeted at persons at risk, ii) early diagnosis (and treatment) of persons with undiagnosed diseases, iii) management of persons with established disease and iv) palliation for persons in the terminal phase.
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