In eukaryotes, these enzymes perform key roles in the synthesis and interconversion of steroids, while in mammals hepatic cytochromes P-450 are vital for the detoxification of many drugs.
Indeed, all Chlamydiaceae species sequenced to date, including C. pecorum, contain homologs for thyX (also known as thy1), glyA, folD, ygfA and fmt that encode enzymes allowing the synthesis and interconversion of carbon-one folate derivatives in the production of dTMP (thymidylate; required for DNA synthesis) and formylmethionine (initiator methionine for protein synthesis).
Investigation of the synthesis and interconversion pathways of the diamine, putrescine, and the polyamines, spermidine and spermine was undertaken.
The 'amino acid synthesis and interconversion and transamination' pathway consists of 17 genes involved in three major reactions, as it is described at REACTOME.
The 'amino acid synthesis and interconversion and transamination' pathway showed the highest classification performance.
Among the pathways that marked averagely high performance in the identification of cancer, the best and the second best pathways are considered, 'amino acid synthesis and interconversion and transamination' and 'unwind of DNA', respectively.
Particularly, we identified 'amino acid synthesis and interconversion' pathway is a good indicator of LUAD (Area Under the Curve (AUC) 0.982 at independent validation).
We explored the pathway-based identification of cancer with 'amino acid synthesis and interconversion and transamination' pathway, which is commonly upregulated in LUAD patients.
Formation and interconversion of chlorofullerenes was investigated in details for C60 ICl system.
Our study also revealed the down-regulation of several genes involved in interconversion of sugar molecules and mitochondrial electron transport system (mETS) that are required for the synthesis of cell wall polysaccharides and fatty acids and maintenance of redox-homeostasis during fibre elongation.
