Exact(10)
For the specific targets, this works as expected.
The large numbers of hits from computation searches then require high throughput assessment using chemical libraries and assays for the specific targets.
The availability of these antimicrobial agents on common platform not only provides useful information but also facilitate the virtual screening process, thus saving time and overcoming difficulties in selecting specific type of inhibitors for the specific targets.
PathogenMiper [22] serves as an in silico multiplex test system, whereby one can check the feasibility of designing a MIP assay for the specific targets one might want to include in a multiplex detection assay.
Oligonucleotides were annealed and ligated into the LentiLox3.7 lentiviral vector (pLL3.7, generously provided by Dr. L. Van Parijs, MIT) under the control of the U6 promoter [55] and used to produce shRNAs for the specific targets.
After initial BLAST analysis, all available sequences for the specific targets were used for sequence alignments.
Similar(49)
The dotted red line shows the highly similar (dissimilarity coefficient of 0.15) known and predicted drug for the specific target.
The online measurement result exhibited negligible response for non-specific adsorption but significant signal changes for the specific target.
RNA interference (RNAi) allows for the specific targeting and silencing of genes, mediated by small interfering RNA (siRNA).
Also, the 19 F-based MR images for the specific targeting of each antibody-conjugated PFC/QD nanoemulsion in various breast cancer cells are shown (Figure 5J-L).
In this case, traditional learning based VS techniques are not suitable here, since there are no or few available training datasets for the specific target.
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