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Our results reveal that TAB1 ubiquitination is the major conduit for the signalling function of the MEKK1 PHD from TGFβRs.
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This seems to alter the signalling function of the receptor, thereby predisposing carriers to disease [ 38].
In view of our interest in the signalling functions of the KDELR, PHB was further investigated.
In fact, since the signalling function of HER3 is mediated through its role as a substrate of HER2 and a scaffold for recruitment of signalling proteins, it presents a difficult target to inactivate by current pharmaceutical approaches.
This has led to doubts about the signalling function of yellow colouration in these species [ 32].
High-throughput screening of the human kinome showing that the signalling functions of cells are linked to endocytosis and vice versa.
Dendritic architecture is regulated by FLRT1 alone whereas the length and complexity of dendrites is regulated by the signalling functions of FLRT1 acting in concert with FGFR1 activation.
Subsequently, I study the signalling function from the standpoint of self-referential systems theory.
Although an appropriate lipid environment seems to be important for some signalling function of uPAR, their role during uPAR endocytosis remains unknown.
This dual function of oxidant/antioxidant systems should nevertheless not compromise the interpretation of antioxidant activities measured in whole animals, because the signalling function is usually spatially restricted and accounts only for a small percentage of the overall activity.
We stress however, that our data do not rule out a signalling function of carotenoid-based plumage in tits.
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