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A total of 33 trials included in Review 1 (4,811 patients) and 16 trials included in Review 2 (29,351 patients) met the inclusion criteria for the primary objectives of the two systematic reviews [4], [6].
The study is powered for the primary objectives, for which the interim analysis requires 500 eligible participants.
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One of the primary objectives for bioinformatics to realize is the automation of annotating cross-matches between databases (Ashburner et al. 2000).
Employment is a natural proxy to measure the impact of the interventions because many such programs list job creation for local residents as one of the primary objectives.
When this work begins in earnest, policymakers should consider increased savings for all Americans as one of the primary objectives of reform.
Formal sample size calculations were not applicable for assessment of the primary objective (safety/tolerability profile).
The evaluable immunogenicity population for analysis of the primary objective included 207 patients (155 adults and 52 children); the most common reason for exclusion from this population was receipt of <3 doses of PCV13 in the sequence assigned.
The Reference Standard is the method that was prospectively identified in the clinical protocol as the method that would be used for the analysis of the primary objective.
Looking back to as early as the mid-1980's, rice geneticists and molecular biologists have always been interested in studying the architecture of promoters, initially for the primary objective of discovering regulatory sequences for spatio-temporal engineering of transgenes.
We chose length of ICU stay as a clinically important outcome for the primary objective as it was one of the key variables found to be significantly associated with vitamin D deficiency in the largest prospective study of 326 children published till date [4].
The main analysis for the primary objective was based on the number of hours between infectious challenge and blood stage parasitaemia.
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