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The recA gene from N. gonorrhoeae is essential for DNA repair, natural DNA transformation, and pilin antigenic variation, all processes that are important for the pathogenesis and persistence of N. gonorrhoeae in the human population.
The α domain of EndoE hydrolyzes the glycans on RNase B, which could be important for the pathogenesis and persistence of a bacterium during human infections [ 66].
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Biofilm formation and migration are important strategies of microorganisms in the pathogenesis and persistence of MCS device infections.
The recent elucidation of pathogenic processes involving tumor necrosis factor α and interleukin-1β in the pathogenesis and persistence of rheumatoid arthritis led to the development of biological modifier agents that have had significant impact on disease severity and progression.
TNF plays a key role in driving the pathogenesis and persistence of RA.
These novel mutations could have important impacts on the pathogenesis and persistence of strains in the host.
This suggests that microstructural brain changes could be involved in the pathogenesis and persistence of gastrointestinal symptoms in DM patients.
Given that TNFα plays an important role in the pathogenesis and persistence of RA, we examined whether IL-17-producing CD4 T cells coexpressed TNFα.
We concluded the serum levels of these inflammatory mediators probably do not have any major role in pathogenesis and persistence of pulmonary complications and do not reflect the degree of severity of pulmonary involvement following SM exposure.
Clinical review: Regulation of food intake, energy balance, and body fat mass: implications for the pathogenesis and treatment of obesity.
These considerable portions of the genomes could provide important functional clues for understanding the virulence and persistence of the pathogen more clearly, anticipating the need for extensive future studies focusing on their possible roles in bacterial pathogenesis.
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