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Whether this exposure is only a modest or a substantial risk factor for the onset and recurrence of LBP is still a matter of debate.
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As Keyes puts it [ 6]: In particular, is languishing a diathesis for, and is flourishing a protective factor against, the onset and recurrence of mental illness?
Conclusions: Interpersonal impairment is a stable feature of depression, a significant challenge to treatment, and may reflect underlying vulnerability to the onset, and recurrence, of depressive experiences.
Recent work has identified Behavioral Approach System (BAS) sensitivity as a risk factor for the first onset and recurrence of mood episodes in bipolar disorder, but little work has evaluated risk factors for the prospective development of hypomanic symptoms in individuals at risk for, but without a history of, bipolar disorder.
This idea suggests that negative cognitive factors emerge during stressful situations, and that this cognitive reactivity is critical for the onset, relapse, and recurrence of depression.
There is also emerging evidence that insomnia is not only a symptom of major depression, but also is commonly a comorbid disorder that may serve as a risk for first onset and recurrence of depression.
Further, there continues to be support for the effectiveness of cognitive-behavioral interventions to prevent the onset, relapse, and recurrence of a number of psychological disorders (Hollon 2003).
Cognitive models propose that biases in the processing of emotional information contribute to the onset, maintenance and recurrence of depression.
Previous studies confirmed that poor social support was related to the onset, relapse, and recurrence of depressive disorder [ 36].
To resolve the conflicting data on lifetime versus current depression for this G × E interaction in our sample, we are currently gathering more comprehensive data on factors such as age of onset of abuse, age of onset, and recurrence of depression symptoms in the current sample which will allow us to more closely analyze the roles of these factors in the current sample.
Therefore, it is difficult to distinguish new onset and recurrence of disease in this study.
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