We hypothesized that if the influence of the MD is critical for the normal, ongoing development of the PFC from the earliest postnatal stages of brain maturation then MD surgical lesions induced just after birth should cause long-term alterations in cognition and behavior in adult rats.
As Aret activity is essential for normal sarcomere growth and myofiber maturation, it is likely that incorporation of the Aret targets such as Strn-Mlck or IFM-specific WupA (TnI) instructs normal myofibril maturation (Supplementary Fig S7).
CKB is required for normal development and mineralization of the growth plate and its expression level is related to chondrocyte maturation stages [ 32].
Bacterial products are also crucial for the normal immune system development; for example, a single bacterial polysaccharide (PSA) from a commensal bacterium Bacteroides fragilis was shown is capable of directing the complete cellular and physical maturation of the developing immune system [15].
At the two weeks time point this connective tissue represents the normal bone healing development and indicated the maturation of the haematoma towards the soft callus phase.
Furthermore, electrophysiological analysis has revealed that GABA depolarises immature neural progenitor cells for the first two three weeks of their neuronal development, an action that is crucial for normal structural and functional maturation as well as network integration (Tozuka et al., 2005; Ge et al., 2006).
In that malignancy, the teratogenic/carcinogenic error occurs in the foetus, but is not manifest until the normal hormonal development and maturation of the reproductive system following puberty.
Bidirectional communication between oocytes and cumulus cells is considered essential for proper maturation or 'programming' of oocytes, which is crucial for normal fertilization and embryonic development [15].
Interactions between oocyte and the surrounding cumulus cells at germinal vesicle (GV) stage are considered essential for proper maturation or 'programming' of oocytes, which is crucial for normal fertilization and embryonic development.
Ubiquitous epigenetic mechanisms represent an essential element of normal development and maturation.
