The increasing number of multiresistant bacteria pose a constant challenge for medicine and dictate the necessity of developing new antimicrobial compounds to treat life-threatening infections.
The bond slip curve is shown to have an approximately triangular shape for a linear adhesive but to have an approximately trapezoidal shape for a nonlinear adhesive, indicating the necessity of developing different forms of bond slip models for different adhesives.
Additionally, the existence of 16 different FA genes, each of them with multiple mutations potentially accounting for the disease, would imply the necessity of developing individualized targeted gene therapy strategies in FA patients.
In hiPSC-derived CM-based cell therapy, billions of cells are required for adequate improvement of cardiac performance3,20, emphasizing the necessity of developing a new method that promises safety and efficacy in hiPSC-based therapy.
As such, the necessity of developing algorithms for solving these complex property models, most often containing molecular descriptors of varying type (e.g. information theoretic, charge based, constitutional) and dimensionality (e.g. 1D, 2D, 3D), within a large search space is realized.
This underscores the large interindividual variability in daily water needs, as well as the necessity of developing biomarkers for adequate fluid intake that are tailored to physiological indicators.
This fact, coupled with the increasing demand of reproducible, high dimensional accurate coatings on free-form surfaces, leads to the necessity of developing software tools for optimized robot trajectory generation.
With the shift from bench to bedside underway, the necessity of developing an approach for the return of clinical genomic results has gained urgency.
