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GATA-3 is required not only for the generation of common ILC progenitors, but also for the maintenance and function of ILC2s.
By intersecting the resulting lists of differentially regulated genes we identify a subset of molecules that are downregulated in all three circumstances, and thus may be particularly important for the maintenance and function of normal, quiescent HSC.
Angpt1 is thus dispensable for hematopoiesis and for the maintenance and function of HSCs in normal adult mice.
RANKL is the primary mediator of osteoclastogenesis and is essential also for the maintenance and function of mature osteoclasts.
Glioblastoma mitochondria may be required for the maintenance and function of invasive pseudopodia (Arismendi-Morillo et al., 2012), which mediate the infiltration of cancer cells into the brain.
The precise balance of self-renewal and differentiation of stem cells is critical for the maintenance and function of a tissue or organ throughout life-time.
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In summary, regulation of MeCP2 expression is complex, multifactorial, and crucial for the proper maintenance and function of the CNS.
Minerals are required for maintenance and function of the skeleton, nerves, and muscles.
E-cadherin is required for the maintenance of architecture and function of the intestinal epithelium.
Thus, the maintenance and restoration of oyster reefs is vital for properly functioning estuarine ecosystems.
Differential regulation of gene expression provides specific sets of proteins for the maintenance of cellular function under altered ambient conditions.
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