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Because only 3% of the seeds produced by our largest pollen load contained expb1, another mutation that is responsible for the large effect on pollen performance that we observed would have to lie no more than 3 cM away from the EXPB1 locus to cause this skewed ratio.
However this explanation did no account for the large effect in Barcelona.
This could be a reason for the large effect size of CCS.
Although within-person confounding was possible, it is unlikely that unmeasured confounding could account for the large effect estimate we observed.
Another explanation for the large effect in the Danish study is the much lengthier intervention time (42.5 h versus 5 to 12.5 h in the other studies).
An even more important reason for the large effect size reported by Dawson et al. may have been a misclassification of the alcohol cases correlated by the outcome measure.
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For example, the large effect of AGPAT6 on FY could help to more precisely map the smaller effects of this locus on PY.
One possible explanation for the large effects in this trial was the high accessibility and possibility to have an intensive contact with the therapist during treatment.
Given the now well established main effect sizes discussed above, it seems unlikely, even allowing for the large effects observed in an interaction analysis, that any of these studies is sufficiently well powered to detect an effect.
Most telling is the large effect for 4-CN-Phe 4-CN-Phe 4-CN-Phe
This could account for the larger effect of social manipulation upon the tuning width in canaries.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com