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Interestingly, signaling pathways required for the initiation and execution of programmed cell death, or apoptosis, are activated during myogenesis [4], [5].
However, accumulating evidence now suggests that reactive oxygen species (ROS) may act as signaling molecules for the initiation and execution of the apoptotic death program in many, if not all, current models of apoptotic cell death [ 23, 24].
These findings suggest that the molecular machinery required for the initiation and execution of programmed cell death may exist in Acanthamoeba [ 18, 19], although biochemical features (metazoan counterparts) and homologs of proapoptotic proteins that orchestrate programmed cell death in cyst-forming free-living protists are yet to be identified.
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For example, conserved domains, HMMs, multiple sequence alignments, molecular structures and other information for many of the genes and proteins involved in the initiation and execution of apoptosis in metazoans are likely to be available in various databases.
Thanks also to Gunilla Jonsson and Marc Karlsson, who were instrumental in the initiation and execution of the project, respectively, and to Magnus Pettersson for statistical advice.
These caspases are essential to the initiation and execution of the apoptotic process.
The current study was designed to examine the regulatory role of mitochondrial bioenergetic function in controlling the initiation and execution of the apoptotic process of OHCs.
Nonetheless, a systematic and integrative analysis of the molecular mechanisms underlying the initiation and execution of the inflammatory response following CS/CPB is still needed.
Mitochondria are responsible for the supply of most of the energy needed by human cells, and have a key role in the initiation and execution of apoptosis.
Our findings emphasize that Cdk1 has multiple roles during the initiation and execution of anaphase.
The initiation and execution of apoptosis is mediated through major cellular organelle, mitochondrion.
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