Suggestions(4)
Exact(1)
The study was not interventional for the implementation of the de-escalation but this was a choice of the attending physicians.
Similar(59)
The implementation of a de-escalation directed protocol for antibiotic management compared to a more liberal strategy with no de-escalation may answer this question.
In an observational, single-center study, Montravers et al. [47] prospectively analyzed the characteristics and outcomes of anti-infective de-escalation during healthcare-associated intra-abdominal infections and found that the presence of non-fermenting Gram-negative bacilli (NFGNB) and MDROs limited the implementation of a de-escalation program.
Next, we sought to study factors associated with the implementation of de-escalation (Table 1).
We also tried to elucidate factors influencing the implementation of de-escalation.
Prior antibiotic administration and the low use of bronchoscopic techniques may have influenced negatively the implementation of de-escalation.
To this end, the determination of factors influencing the implementation of de-escalation is important in order to increase its use.
Further studies are needed to evaluate the magnitude of changes in antibiotic use and clinical outcomes resulting from the implementation of de-escalation strategies.
In response to this, a consensus has emerged emphasizing the implementation of de-escalation therapy or discontinuation of antibiotics once culture results and susceptibility findings are available.
Basic demographic and clinical characteristics of the de-escalation and non-de-escalation groups are summarized in Table 1.
Barriers and enablers to the implementation and effectiveness of de-escalation techniques in practice are not well understood.
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