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In addition to the non-physiological nature of alum, this adjuvant is not required for the generation of an acute allergic inflammatory response using the antigen ovalbumin (OVA) [ 10].
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To corroborate these findings, we next investigated the anti-inflammatory effects of FBP in antigen-induced-arthritis (AIA) model, which involves adaptive immunity for the generation of the acute inflammatory response17,19.
The results of this study validate the concept that IL-1β is a key mediator in the generation of acute gouty arthritis flares and hence an appropriate therapeutic target for treatment of acute gouty arthritis and prevention of flares.
It remains to be elucidated why an established immunity capable of containing the viral burst during acute infection gradually loses its grip over the virus, allowing for the generation of these mutant viruses.
These findings provide a framework for explaining the pattern that acute stress disrupts the generation of LTP in mPFC and DH, while it simultaneously facilities LTP in the amygdala.
However, assessing muscle strength may be difficult in the early stage of acute disease, and the use of PENT could be of value in assessing the generation of the action potential, which is an essential pre-requisite for muscle contraction.
The generation of oxidative stress and ROS was markedly enhanced in acute kidney IR animals in comparison to the sham controls.
In many surveys, it was found that acute exercise accelerated the generation of LPO [ 41, 42].
Paradoxically, evidence suggests that acute hypoxia contributes to the generation of ROS.
The present study therefore suggests that acute administration of folic acid leads to the generation of oxidative stress and altered membrane architecture responsible for folic acid induced ARF.
The generation of the pro-inflammatory cytokines IL-6, TNF-α, and IL-1β fuel the acute phase response (APR).
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