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Here we investigate thymus decellularization approaches that preserve major extracellular matrix components and support thymic epithelial cells for the generation of a functional thymic microenvironment with improved T cell output.
Signaling through the B cell antigen receptor (BCR) is required for the generation of a functional mature B cell repertoire (3, 5), and multiple components of the BCR signalosome regulate biochemical events after BCR engagement.
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The strategy allows for the generation of a homogeneous ADC product via functional, antibody interchain disulfide-bridging that displays retention of binding to its target antigen.
Our results show that IL-6 production by DCs is dispensable for the generation of fully functional CD8+ Tm cells.
The deletion which occurs early in the gene would not allow for the generation of even a shorter functional protein.
This observation reinforces the notion that establishing culture conditions that promote appropriate maturation represents a significant hurdle for the generation of functional beta cells in vitro.
Today laser cladding is a well known technique for the generation of functional layers and/or regeneration of parts.
Many novel independent sequences were recovered with moderate affinity and high specificity for ATP, validating this scaffold for the generation of functional molecules.
These processes are crucial for the generation of functional antibodies.
Previous studies have shown that CD4+ T-cell help is required for the generation of functional CD8+ T-cell responses [13], [14], [15], [18], [23], [24], [25].
Genomic imprinting is the process responsible for the generation of functional differences between maternally- and paternally-derived alleles at the same gene [12] [15].
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