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We apply the proposed algorithm to the acetylcholinesterase, a well-known enzyme in neurobiology, and show how one can gain insight into the "breathing dynamics" of a structural funnel necessary for the function of the protein.
The VFT2 domain is totally conserved within each of the two major BvgS types, indicating its pivotal role for the function of the protein.
It is likely that certain residues in certain positions are required for the function of the protein and the de novo design may be focused on the set of sequences which are more stable than the native ones, but in the vicinity of the native so that they retain their function.
Binding sites in a protein structure are important for the function of the protein.
This mutation is novel, and predicted to be highly damaging for the function of the protein.
We have shown that the terminal tryptophan residue of Mec1 is required for the function of the protein.
Similar(37)
Mechanical flexibility is crucial for the function of proteins.
Only about 1percentt of the genome codes for proteins, however, and the challenge has been to figure out the function of the other 99percentt, which for years was termed "junk DNA" because it did not code for proteins.
The function of this protein is unknown.
The ability to ablate the function of a specific protein is a powerful tool for investigating protein function.
THE function of transformation proteins coded for by RNA-and DNA-containing tumour viruses is a major question in oncology.
More suggestions(16)
for the function of the mitochondria
for the majority of the protein
for the source of the protein
for the function of the p53
for the half of the protein
for the visualization of the protein
for the purification of the protein
for the part of the protein
for the accumulation of the protein
for the turnover of the protein
for the function of the system
for the transfer of the protein
for the size of the protein
for the isolation of the protein
for the trafficking of the protein
for the function of the kidney
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