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Nevertheless, considering the lack of efficacious pharmacological treatments in this basal ganglia disorder, our findings might provide the basis for the development of more specific drugs against HD.
Molecular profiling may also identify groups of genes, which may provide targets – at a single gene and a pathway level – for the development of more specific therapeutic molecules.
The elucidation of the key molecular targets of HDACi involved in glioma cell death is relevant for the development of more specific therapeutic strategies.
The availability of the GAK crystal structure provides the basis for the development of more specific inhibitors for the treatment of these cancers.
Understanding the genetic factors that influence Gc sensitivity is crucial for elucidating the mechanisms responsible for resistance and also for the development of more specific treatment regimens.
While no single approach can suffice for what are unique contexts, this broader framework can be used as a baseline for the development of more specific national and regional approaches.
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Thus, the search for alternative therapies and/or the development of more specific drugs is a challenge.
This is important for patient care, because it may lead to the development of more specific treatment options and new biomarkers for disease activity and treatment response.
Together with the development of more specific radionuclide tracers for breast cancer, this may further improve the detection rate of PET/CT [22].
A better understanding of this complex regulatory system may allow the development of more specific therapeutic strategies for heart diseases.
Recently, the development of more specific, in-vitro assays for LTBI – interferon-gamma (IFN-γ release assays (IGRAs), has offered an alternative approach to LTBI diagnosis.
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