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The analysis of the contour maps from each model provided insight into the structural requirements for the development of more active sglt inhibitors, and on the basis of the models 8 new sglt inhibitors were designed and predicted.
Better understanding of this key mechanistic step and the function of the metal center in catalysis will improve our understanding of the enzymatic reactions and allow for the development of more active bio-inspired systems.
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The method is simple and easy to implement to approximate potential-dependent activation energies at the computational cost of a singly hydrogenation barrier calculation and can aid in the development of more active and selective catalysts for electrochemical reactions.
Despite the development of more active and less toxic antifungal agents, mortality rates for invasive fungal infection remain unacceptably high.
Considerable progress has been made in the past two decades in the development of more active and selective cobalt and iron catalysts and more effective reactor/process technologies[3].
Cost issues are being addressed with the development of more active congeners and more efficient methods of production.
The active competition that ensued must have greatly accelerated evolutionary change, serving as a powerful force for the development of more efficient cells.
It has been demonstrated that both the steric and electrostatic factors should appropriately be taken into account in future rational design and development of more active and more selective PDE5 inhibitors for the therapeutic treatment of erectile dysfunction (ED).
Alternatively, more vigorous activity may lead to the development of more muscle mass and hence more metabolically active tissue.
With the development of more refined measurement technologies, more and more evidence showed that the cochlea is active and nonlinear.
The results were used for catalysts evaluation and as a tool for the development of a new, more active and stable formulation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com