Sentence examples for for the development of crc and from inspiring English sources

Together, these observations suggest that methylation levels in the normal colonic mucosa could serve as markers of risk for the development of CRC and in particular for the closely related MSI+/CIMP+ subgroup.

28, 29 Overall, miR-9 is associated with the development of CRC and could be used for CRC molecular-targeted therapies.

Obesity, which is one of the most serious healthcare problems worldwide, is a significant risk factor for the development of CRC [ 4, 5].

Continuous activation of the MAPK signalling pathway is of critical importance for the development of CRCs.

QKI5/6 might contribute to the development of CRC by controlling β-catenin and p27 Kip1 signalling.

Moreover, CYP1A2 is critical for the metabolic activation of dietary heterocyclic aromatic amines (HCA) which are mutagenic and have been implicated in the development of CRC [ 17- 23].

Thus, molecular analysis of FDNs is important for achieving a better understanding of the mechanism in the development of CRCs.

Estimates of the natural history of CRC progression from normal colorectal epithelium through the development of adenomas, CRC and eventual mortality were obtained, as were the performance measures of sensitivity and specificity for each of the screening modalities.

Moreover, mutations involved in DNA mismatch repair may account for the development of 10%to15%5% of sporadic CRC and HNPCC.

We recently identified specific germline EDMs in POLD1 and POLE that are causative for the development of multiple colorectal adenomas and CRC.

The adenoma carcinoma sequence is well accepted as a major pathway for the development of colorectal cancers (CRCs) (Morson, 1968).