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Thus there is an imperative need for developing non-invasive screening tests for the detection of CRC and adenomas, and hence many current studies are evaluating serum markers.
However, our findings do not suggest that these serum parameters may be clinically relevant markers for the detection of CRC and especially for early detection.
The need for a noninvasive test has led investigators to explore the use of gene expression microarrays and serum proteomics for the detection of CRC and adenomas.
A recent study in asymptomatic high-risk patients, showed sensitivities of 100%and65%5% for the detection of CRC and all advanced neoplasia, respectively [ 7].
Sensitivities of 100%and65%5% for the detection of CRC and all advanced neoplasia, respectively, were found using the same FIT as was used in the present study at the same cut-off level [ 7].
As we focused on assessing the sensitivity for the detection of CRC and advanced colorectal adenomas, as well as specificity among subjects free of neoplasms, we further excluded participants with non-advanced adenomas (n=401) or with hyperplastic polyps only (n=198).
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A total recognition rate (92.6%), sensitivity (95.2%) and specificity (90.0%) for the detection of CRC were shown.
Diagnostic characteristics of sCD26 and TIMP-1, for the detection of CRC were reported by three studies for each of the two markers.
We further demonstrate that methylated CAHM sequences can be detected in the plasma of patients with CRC, and thus may potentially contribute to assays for the detection of CRC using non-invasive samples.
There is a great variety of methods for the detection of CRC.
There have been several publications examining the potential for miRNAs to act as circulating biomarkers for the detection of CRC.
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