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However, it is already apparent that lifetime imaging adds a useful additional dimension of contrast to fluorescence instrumentation and that the clinical application of FLIM for the detection and delineation of malignancy is now feasible and informative.
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Therefore, identifying and understanding PTMs is critical for gaining a comprehensive understanding of cell biology, the detection and delineation of molecular defects underlying human and other diseases, drug target discovery and validation, and the eventual treatment and prevention of diseases.
The use of FLIM of tissue AF to aid the detection and delineation of neoplastic change is an emerging concept.
The ability to noninvasively detect aberrant vasculature is especially crucial for detection and delineation of brain tumours.
Thus USPIO imaging may be a very attractive alternative to Gd-DTPA imaging and will at least have added value, especially for detection and delineation of diffuse infiltrative brain tumours.
In addition, the next development steps for this algorithm include automated detection and delineation of trabecular bone.
Again, the overall utility of our approach in the detection, recovery and delineation of genes within L. calcarifer is emphasized by its success in our study of β2M.
This complexity has complicated detection and delineation of the metastatic processes.
Detection and delineation of prostate pathology with imaging remains a challenging endeavour.
In general, this percentage clearly exceeds the success percentage of MRI-guided FUS ablation, although MRI is expected to be the most reliable imaging modality for breast cancer detection and delineation.
While the effectiveness of widefield autofluorescence imaging shows potential for detection of oral cancers and delineation of tumor margins, acquiring additional spectral information may increase specificity when imaging benign lesions, especially in a low-risk screening population.
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