In this section we describe the algorithm for the computation of elementary alignments between a set of input cDNA sequences and a genome from the same species.
However, the computation of the reaction barrier of each elementary step is time-consuming, and moreover the understanding of the catalytic systems from the total-energy profiles obtained consequently is not straightforward, let alone rational design of new catalysts.
A serious problem of elementary mode (EM) or extreme pathway (Expa) analysis is that the computational time increases exponentially with an increase in network sizes, which makes the computation of the EMs/Expas expensive and infeasible for large-scale networks.
Although the computation of elementary modes is hindered by computational complexity, recent breakthroughs have allowed applying elementary mode analysis at the genome scale.
The minimality of the extracted networks enables the computation of elementary flux modes for each time point, which are in turn used to characterize the transitional behavior of the network as well as of individual reactions.
This highly comprehensive handbook provides a substantial advance in the computation of elementary and special functions of mathematics, extending the function coverage of major programming languages well beyond their international standards, including full support for decimal floating-point arithmetic.
Part I considers the computation of elementary functions using algorithms based on polynomial or rational approximations and using table-based methods; the final chapter in this section deals with basic principles of multiple-precision arithmetic.
A typical example is the computation of elementary flux modes at the genome-scale, requiring modular decomposition of the networks (Schuster et al. 2002).
One example is the computation of elementary flux modes to represent the feasible solution space of a metabolic network [ 5].
In order to determine all stoichiometrically balanced heterologous pathways H P that can be inserted into the chassis organism to produce a target set T P, we need to constrain the computation of elementary modes only to those that have non-zero fluxes for heterologous reactions.
