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From combined analysis of MD data and paramagnetic profiles, two CXCL12 sites suitable for the binding of small molecules were identified.
These features reduce the potential free energy gain for the binding of small molecules and flexible linear peptide ligands.
These two functional types are sequence related, and all of the proteins contain a common structural domain (SCOP sf53822) for the binding of small molecules [ 25, 26].
Avd provides an attractive robust scaffold for the development of novel receptors, and Avd has many advantageous properties such as high chemical and thermal stability, a deep ligand binding site optimized for the binding of small molecules, and an oligomeric nature enabling signal amplification.
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The increasing temperature could affect the binding of small molecules and protein for different quenching types.
The binding of small molecules to double stranded DNA including intercalation between base pairs has been a topic of research for over 40 years.
Label-free MST is sensitive enough to measure the binding of small molecules.
We further probed quinate and shikimate binding using WaterLOGSY NMR, a technique previously shown to be useful for detecting binding of small molecules to large protein complexes.
Footprinting is a method that has been developed for determining the sequence-specific binding of small molecules, oligonucleotides, or proteins to DNA.
This family of hexameric proteins may provide a useful framework for the construction of proteins that change their oligomeric states in response to binding of small molecules.
The binding process of small molecules and proteins may affect the conformation of proteins.
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