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The protein kinase Aurora-A is a major regulator of the cell cycle that orchestrates mitotic entry and is required for the assembly of a functional mitotic spindle.
Although this domain lacks the phosphotransfer activity, nucleotide binding is maintained and required for the assembly of a functional RNase dimer (Huang et al. 2014).
The central finding of our work is that gradients of cortical MT nucleation are sufficient for the assembly of a functional compartmentalised MT cytoskeleton in wild-type oocytes.
It is probable that more factors are needed for the assembly of a functional complex, but that the genetic approaches used to date have not been able to identify them.
A. tumefaciens strain C58 contains a T6SS gene cluster in which 14 of 23 genes are essential for the assembly of a functional type VI secretion machinery (Lin et al., 2013).
We assume that the oligomerization of Avd, secreted by the pelB signal sequence, occurs in the periplasmic space of E. coli, allowing the display of functional Avd on the phage, as is the case for the display of the antibody Fab fragment, which requires folding of the heavy and light chains for the assembly of a functional antibody molecule [ 24].
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Thus, Lsk1p kinase activity is required for both Lsc1p nuclear localization as well as the assembly of a functional Lsk1p-Lsc1p complex.
First, the assembly of a functional spindle is critical for accurate chromosome segregation.
The assembly of a functional spindle is critical for accurate chromosome segregation.
The assembly of a functional mitotic spindle is essential for cell reproduction and requires a precise coordination between the nuclear cycle and the centrosome.
These results corroborate the conclusion of Aim24 being critical for the assembly of a fully functional MICOS complex.
More suggestions(15)
for the assembly of a genome-scale
for the value of a functional
for the assembly of a connective
for the assembly of a wide
for the lack of a functional
for the construction of a functional
for the development of a functional
for the assembly of a membrane-less
for the release of a functional
for the assembly of a large
for the assembly of a double
for the assembly of a high
for the generation of a functional
for the assembly of a cell-associated
for the presence of a functional
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