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If multiple reports on a particular variation differed, the mutation was classified as nonneutral with respect to that function: that is, a single report of a functionally disruptive mutation was sufficient to classify the variant as nonneutral for the affected function regardless of other existing annotations reporting neutrality of the variant.
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Also transcriptional regulators for the specific affected functions were identified, which deserve further attention, as ETS2, FOSB, KLF4 or PAX2.
Placebo injection with physiotherapy was worse than control at 6 weeks for affected function on VAS, CI with physiotherapy was better than control at 6 weeks for overall complaints on VAS, pain free dorsiflexion of wrist and isometric extension of third finger.
For the upregulated DEGs, the most affected functions were associated with biosynthetic and metabolic processes (Fig. 3a).
For the continuous responses (pain, affected function, and overall complaints on VAS scales, grip strength ratios and Pain Free Function Index), we used a linear GEE regression model adjusted for the same covariates.
Inclusion criteria included individuals with psychologic evaluation for persistent pain that affected function.
The ultimate focus of treatment for spasticity should be towards functional improvement, even though this may be at the level of passive function (ie, ease of caring for the affected limb), as opposed to active function (ie, active use of the limb in functional tasks).
The Ebola outbreak is a catastrophe for the affected countries.
This makes convergence to reality impossible for the affected dimensions.
A red alert was also declared for the affected regions.
Results for the affected and the non-affected side are presented within the same diagrams.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com