Sentence examples for for the activation of this microRNA from inspiring English sources
In a series of elegant and well-integrated experiments to inhibit miRNA function, mutate miRNA-binding sites in target reporters, and use of siRNA to knockdown Mef2 expression, the authors provide compelling evidence that Mef2 was necessary for the activation of this microRNA gene cluster.
We demonstrate that ecdysone exerts this function by inducing a heterochronic network encompassing the activation of the microRNA lethal-7, which suppresses its target gene chronologically inappropriate morphogenesis.
Interestingly, the rearrangement of several subgenes (i.e. V2 family) for lambda light chain immunoglobulin is coupled with the activation of microRNA miR-650, which further influences biology of B-cells.
Activation of microRNA-200a, microRNA-200b, microRNA-429, and microRNA-200c is closely correlated with the global CpG methylation reduction.
Whether or not the activation of calpain and the subsequent cleavage of Dicer can account for changes in the microRNA profile associated with other diseases remains to be determined.
Deregulated microRNA networks add another level to the complexity of the activation of RASF.
In course of molecular G1/S transition regulation, complex relationships including direct microRNA-mRNA interactions and activation of microRNA transcription exist between E2F transcription factors [29], [30], [31] and microRNAs of the miR-17-92 miR-17-92 miR-17-92 most intensively clustererized microneA families.
Additionally, efforts have been made to develop computational methods for the integration of microRNA, microRNA targets, and transcription factors into biologically relevant pathways, circuits, and networks [46, 47].
Li, C. H. et al. Hepatitis B virus X protein promotes hepatocellular carcinoma transformation through interleukin-6 activation of microRNA-21 expression.
Han, J. et al. Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex.
