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Second, the temporal action of CD4+ T cells for the activation and differentiation of CD8+ cells remains undefined.
Major differences in the immune response network appeared on day 7 p.i., with upregulation of additional chemokines and cytokines responsible for the activation and differentiation of innate and adaptive immune cells (see the non-starred red nodes on the right panel of Figure 5).
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Our work demonstrated the temporal function of CD4+ T cell-derived IL-2 for governing the activation and differentiation of CD8+ T cells.
The canonical NF-κB pathway is well known for its role in the activation and differentiation of T cells [ 54].
The textbooks tell that three signals are required for full activation and differentiation of resting T cells.
Approaches of targeting excessive activation and differentiation of osteoclasts were considered as an effective treatment option for osteoporosis or osteopenia.
Stat5 activation is required for the proliferation and differentiation of mammary epithelial cells during pregnancy and lactation [17], while activation of Stat3 is required for mammary gland involution [18].
Whereas, prolonged p38 activation is required for the maturation and differentiation of chondrocytes and it is necessary for endochondral ossification.
This contrasts with our data for Prospero, which represses neuroblast genes and is required for the activation of differentiation genes.
Hence, other co-stimulatory molecules may override the absence of B7 co-stimulation for T cell activation and differentiation into Th17 cells [39].
These results indicate that FAK activity is important for TGFβ-mediated Akt activation and myofibroblast differentiation of primary HLF.
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