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The different possible and most relevant faults that may occur and must be dealt with are identified and requirements for testing approaches concerning component failures are derived.
A number of studies have been conducted to characterize the endocrine potential of municipal effluents [24, 25], surface water [26 28] and sediments [26, 27, 29, 30], and there has been increasing awareness of the need for testing approaches targeting EDCs to be included into current environmental assessments and monitoring [31 36].
Thus, the models reveal novel aspects of cancer evolution in carriers of germline BRCA2 mutations, provide new insights into the tumour suppressive role of BRCA2, and establish valuable new preclinical settings for testing approaches to pancreatic cancer therapy; together, these features emphasize the value of GEMMs in cancer research.
Priorities must be situated in a clear timeframe – defining the short-term and the long-term priorities will help build developmental space for testing approaches and increasing capacities and resources.
On the other hand, larger animals, such as dog and sheep, are very expensive and not appropriate to establish new experimental conditions, although they are useful for testing approaches established in smaller animal models.
The structure of this dataset allows for testing approaches considering varying levels of pedigree and/or genomic relationships because animals from multiple generations and both sexes have high-density genotypes.
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This system is valuable for systematically testing approaches for increasing HR efficiency and accuracy.
Empirical testing approaches for the game-testing phase have been explored by only a few researchers.
The chapter also discusses some unique testing approaches for the RF sealing process.
We will also be exploring permutation testing approaches for evaluating implication-score significance.
For further discussion on multiple testing approaches, see Dudoit et al. (2003).
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