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The reasons for terminating the trial will be safety or poor study performance (e.g. slow accrual, high losses to follow-up and poor quality control).
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We performed a binary outcome simulation study of a response adaptive randomized three-arm clinical trial with treatment arms A, B, and A&B that allowed for dropping an inferior treatment arm and terminating the trial early for superiority during any of 4 interim analyses.
Patients will be informed that terminating the trial will have no implications for future treatment.
The investigators are responsible for making the final decision to terminate the trial.
The DMC can advise to terminate the trial prematurely for safety reasons.
Larger deviations or behavioral errors terminated the trial.
Choice response terminated the trial.
For NO-GO stimuli, a period of 10 s without a response in the presence of the stimulus terminated the trial and initiated the next trial.
Prior to the start of the trial the DSMB defined criteria to terminate the trial prematurely.
The experimenter terminated the trial immediately after the verbal response and then initiated the next trial.
A premature button press prior to the appearance of the circle also terminated the trial.
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