Sentence examples for for targeted modification from inspiring English sources

The engineered construct (i.e. GNG-GA3) identified through ZifBASE can be used to target the interleukin-2 receptor gamma subunit gene sequence for targeted modification.

Engineered zinc finger nuclease (ZFN mediated genetic modification in somatic cells combined with somatic cell nuclear transfer (SCNT) technology provides a new approach for targeted modification in pig genome.

Moderate correlations between seven continuous traits, such as methane production or microbial protein production, and the presence and abundance of 17 OTUs were found, indicating scope for targeted modification of the microbiome to improve the energetic efficiency of rumen microbial synthesis and reduce the greenhouse gas footprint of ruminants.

In a similar manner, the user can predict the ZFP binding sites for targeted modification of plant and mammalian genomes.

On the other hand, measurement of gene editing at the single cell level, employed assays for targeted modification of a mutated GFP.

From these, candidate genes were identified which could represent potential leads for targeted modification of the S. rolfsii metabolism for increased scleroglucan yields.

A series of novel coumarin derivatives were rationally designed and synthesized by use of a complex catalytic system for a targeted modification at the above sites.

A special apparatus allowing for the targeted modification of the physicochemical characteristics of dispersive systems via a self-organised liquid flow (Bénard-Marangoni or Railegh-Bénard instability) was constructed.

However, an increasing demand for tissue-specific Cre-expressing rat lines can be anticipated in the near future, as the first successful gene targeting in rat embryonic stem cells was recently published [ 51] and several other tools for the targeted modification of the rat genome, such as zinc finger nucleases [ 11, 12] or transcription activator-like effectors [ 52], are emerging.

An alternative, and more widely investigated, strategy for the targeted modification of plant genomes is the production of a DNA break at a unique chromosomal location using a site-specific endonuclease that recognizes a relatively long, and therefore unique, DNA sequence.

This work represents the first guide for using steric-block antisense oligos as tools for effective and targeted modification of RNA splicing.