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Tolerance towards the effects of inhaled β2-AR agonists generally is more easily shown for systemic parameters than for airway effects and can be substantial.
Thus, the therapeutic effect of the anti-VEGF is robust and occurs for a wide range of values for systemic parameters and drug properties.
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Two days after chamber implantation, polyethylene-50 catheters were inserted into the internal carotid artery and external jugular vein for evaluation of systemic parameters (mean arterial blood pressure (MAP), heart rate) and infusion of study drugs.
The aim of the present investigation was to search for correlations between the magnitude of coronary artery disease, as assessed by angiography, and a number of systemic parameters.
Acute changes in water temperature, for example, have a strong effect on systemic parameters such as heart and ventilation rate of Daphnia spp. (e.g. [ 3]).
For interpretation of ANN models, a means of evaluating how systemic parameters contribute to model output is essential.
In none of the experiments systemic parameters changed significantly during the infusions.
Most of these models focus on intracellular biochemical reactions and require accurate estimation of a very large number of system parameters for providing systemic understanding of underlying processes.
For many years, the PAC was considered the 'gold standard' for monitoring systemic hemodynamic parameters, such as cardiac output, left ventricular preload, and systemic oxygen delivery.
The second group included 28 patients undergoing major abdominal surgery, with negative parameters for systemic inflammatory response syndrome (Table 1).
The pharmacokinetic parameters used for systemic catumaxomab were AUC 0, tlast), Cmax, tmax, Cmax3, and Cmax4 (the latter two parameters are the maximal plasma concentrations after the third and fourth infusions, respectively).
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