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The commercial availability of peptides and proteins and their advantages as therapeutic agents have been the basis for tremendous efforts in designing delivery systems for such agents.
For such agents, pegylated liposome delivery offers improved chemical stability of encapsulated drug, enhanced accumulation in tumors, and prolonged drug exposure.
Decision theory should prescribe a rational choice for such agents, and evidential decision theory may not do that correctly, as Lewis (1981 10 111) and John Pollock (forthcoming) argue.
Even though agent-based simulations are a promising technology for this, there are many problems associated with it in terms of more realistic models for such agents to behave or perform.
These data add melatonin to the growing list of compounds that increase total sleep after administration into the MPA, and suggest that the MPA may be a common site of action for such agents from a variety of pharmacologic classes.
The results of this study support the present acceptable safety profile for such agents.
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The requirements for such agent-based design support are discussed and possibilities for its realisation, with the aid of Web technology, in a distributed design environment are explored.
In Part I of this series of papers, we developed a language called Agent Programs for defining the operational behavior of software agents and defined a set of successively more satisfying (epistemically) semantics for such agent programs.
They provided a series of successively more sophisticated semantics for such agent systems, and showed that as these semantics become epistemically more desirable, a computational price may need to be paid.
The viral serine protease NS2B-NS3 is a promising target for the development of such agents.
Many modelling languages have been proposed in recent years to represent the internal architectures of such agents, for instance the UML profiles.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com